Development of novel piezoelectric materials based on nanostructured self-assembled peptides (BioPiezo)
Project Reference: PTDC/CTM-CTM/31679/2017 (CENTRO-01-0145-FEDER-031679)
Date: from 2018-06-01 to 2021-12-31
Coordinator: Dr. Svitlana Kopyl
CICECO – Aveiro Institute of Materials,University of Aveiro
Partner institution: Center for Neurosciences and Cell Biology, University of Coimbra.
Summary
| The self-assembly of bio-organic materials is currently an emerging field of investigation because of the excellent possibilities afforded by its unique anisotropic structure, combined with variability due to non-covalent interactions between molecules. The study of DNA, proteins and peptides has become an object of intense research due to their ability to self-assembly into nanoscale objects with important functional properties. Piezoelectricity is the ability of non-centrosymmetric crystals to produce mechanical stress/strain under electric field. This fundamental property has long been used in numerous devices such as sensors and actuator. The materials used by now are not environmentally friendly. Recently discovered by our group (University of Aveiro), strong piezoelectric activity in peptide nanotubes (PNTs) holds a great promise for using piezoeffect in numerous applications. A lot of work is done to investigate the diphenylalanine structure and the properties, but the ferroelectricity and sequence of phase transitions (especially the low temperature) are still open questions. The general objective of this project is to discover the nature of these specific interactions; the study of these functional properties is extremely useful for other applications of self-organized peptides in new biosensors, microresonators, organic electronics, etc. Dielectric, piezoelectric and other relevant properties will be investigated. Nuclear magnetic resonance methods will be applied for the understanding of the structural arrangement in PNTs, nature of the phase transition and their role in the piezoelectricity of the material and their stability. Peptides are naturally suited to biomedical applications because of their general biocompatibility with the human body. The project aims to develop devices (eg piezoelectric array or biosensors) that can be used for the diagnosis and / or treatment of heart diseases, namely acute myocardial infarction, one of the main reasons for death in Portugal. |
Main results
| Book chapter:
Vladislav Slabov, Svitlana Kopyl, Marco P. Soares dos Santos and Andrei Kholkin. Piezoelectricity in Self-Assembled Peptides: A New Way towards Electricity Generation at Nanoscale (chapter in book: Nanogenerators, IntechOpen, ISBN: 978-1-83881-059-7) Papers: 1. M. Wojtas, V. Kinzhybalo, I. Bdikin, A. L. Kholkin. Crystal Structure and Strong Piezoelectricity of New Amino Acid Based Hybrid Crystals: [H-β-(3-Pyridyl)-Ala-OH][ClO4] and [H-β-(4-Pyridyl)-Ala-OH][ClO4]. Crystal Growth & Design 2019, 19(5), pp.2583-2593 2. V. Slabov, D. Vasileva, K. Keller, S. Vasilev, P. Zelenovskiy, S. Kopyl, V. Ya. Shur, A. VinogradovA. L. Kholkin. Controlled Growth of Stable β-Glycine via Inkjet Printing. Crystal Growth & Design 2019, 19(7), pp.3869-3875. Publication Date: May 30, 2019 3. V.S. Bystrov, P.S. Zelenovskiy, A.S. Nuraeva, S. Kopyl, O.A. Zhulyabina, V.A. Tverdislov. Molecular modeling and computational study of the chiral-dependent structures and properties of self-assembling diphenylalanine peptide nanotubes. Journal of molecular modeling. 2019, 25(7):199. Publication Date: June 25, 2019 4. P. Zelenovskiy, A. Nuraeva, S. Kopyl, S. Arkhipov, S. Vasilev, V. Bystrov, D. Gruzdev, M. Waliczek, V. Svitlyk, V. Shur, L. Mafra, AL. Kholkin. Chirality-dependent growth of self-assembled diphenylalanine microtubes. Crystal Growth & Design 2019, 19, 11, 6414–6421 5. V. Slabov, S. Kopyl, MP. Soares dos Santos, AL. Kholkin. Natural and Eco-Friendly Materials for Triboelectric Energy Harvesting. Nano-Micro Letters, 2020, 12 (1), 42. 6. A. Krylov, S. Krylova, S. Kopyl, A. Krylov, F. Salehli, P. Zelenovskiy, A. Vtyurin, A. Kholkin. Raman Spectra of Diphenylalanine Microtubes: Polarisation and Temperature Effects. Crystals, 2020, 10 (3), 224. 7. PS. Zelenovskii, EM. Domingues, V. Slabov, S. Kopyl, VL. Ugolkov, F. Figueiredo, AL. Kholkin. Efficient Water Self-Diffusion in Diphenylalanine Peptide Nanotubes. ACS Appl. Mater. Interfaces 2020, 12, 24, 27485–27492. 8. V. Bystrov, J. Coutinho, P. Zelenovskiy, A. Nuraeva, S. Kopyl, O Zhulyabina, V. Tverdislov. Structures and Properties of the Self-Assembling Diphenylalanine Peptide Nanotubes Containing Water Molecules: Modeling and Data Analysis. Nanomaterials 2020, 10(10), 1999. 9. PS Zelenovskii, K. Romanyuk, M. S Liberato, P. Brandão, F. F Ferreira, S. Kopyl, L. M Mafra, W. A Alves, A. L Kholkin. 2D Layered Dipeptide Crystals for Piezoelectric Applications. Adv. Func. Mater. 2021, 31 (43), 2102524. 10. V. Bystrov, A. Sidorova, A. Lutsenko, D. Shpigun, E. Malyshko, A. Nuraeva, P. Zelenovskiy, S. Kopyl, A. Kholkin. Modeling of Self-Assembled Peptide Nanotubes and Determination of Their Chirality Sign Based on Dipole Moment Calculations. Nanomaterials 2021, 11(9), 2415. 11. K. Romanyuk, V. Slabov, D. Alikin, P. Zelenovskiy, MR P Correia, K. Keller, RAS Ferreira, S Vasilev, S. Kopyl, A. Kholkin. Piezoactive dense diphenylalanine thin films via solid-phase crystallization. Appl. Mater. Today 2022, 26, 101261 https://www.ua.pt/en/demac/provapublicahelderduartemagalhaesbaptista
Conference presentations: 1. S. Kopyl, F. Salehli, S. Vasilev, P. Zelenovskiy, A. Nuraeva. Esin, V. Shur and A.L. Kholkin. ANM 2017 – 9th International conference on Advanced Nanomaterials, Aveiro, Portugal, 19-21 July 2017 // Self-assembled diphenylalanine microtubes: emerging properties and applications (invited talk) 2. S. Kopyl, A. Nuraeva, S. Vasilev, P. Zelenovskiy, V.V. Yuzhakov, S. Tofail, V.Ya. Shur, A.L. Kholkin. International Conference SPM-Scanning Probe Microscopy, Ekaterinburg, Russia, 28-30 August 2017// Chemically stable diphenylalanine peptide microtubes:structure, properties, application. (poster presentation) 3. A.L. Kholkin, F. Salehli, S. Kopyl, E. Seyedhosseini, P. Zelenovskiy, A. Nuraeva, S. Vasilev, D. Vasileva, A. Esin, V. Ya. Shur. International Conference SPM-Scanning Probe Microscopy, Ekaterinburg, Russia, 28-30 August 2017// Novel supramolecular biomaterials for piezoelectric applications. (invited talk) 4. V.S. Bystrov, S.A. Kopyl, A.L. Kholkin, O.A. Zhulyabina, V.A. Tverdislov. International Conference SPM-Scanning Probe Microscopy, Ekaterinburg, Russia, 28-30 August 2017// Investigation of physical properties of diphenylalanine peptide nanotubes having different chirality (poster presentation) 5. A.L. Kholkin, F. Salehli, S. Kopyl, S. Vasilev, P. Zelenovskiy, V.Ya. Shur, D. Chovan, S.A.M. Tofail. ISAF-FMA-AMF-AMEC-PFM Joint Conference (IFAAP2018), Hiroshima, Japan, 27 May – 1 June 2018 // Can the water be piezoelectric/pyroelectric: evidence from self-assembled peptides (invited talk) 6. S. Kopyl, K. Romanyuk, P. Zelenovskiy, S.Vasilev , A. Nuraeva, D. Vasileva, D. Chovan, S.A.M. Tofail, A.L. Kholkin. Jornadas 2018, CICECO-Aveiro Institute of Materials, 11-12 June, 2018 // Amino acids and self – assembled peptides for piezoelectric applications (poster presentation) 7. S. Kopyl, V.S. Bystrov, A. Nuraeva, P. Zelenovskiy, S. Vasilev, S.G. Arkhipov, V.Ya. Shur, A.L. Kholkin. 15th International Conference on Nanosciences & Nanotechnologies (NN18), Thessaloniki, Greece, 3-6 July 2018 // Diphenylalanine peptide nanotubes with different chirality: structure and properties. (oral presentation) 8. S. Kopyl, V. S. Bystrov, A. Nuraeva, P. Zelenovskiy, S. Vasilev, S. G. Arkhipov, V. Ya. Shur, A. L. Kholkin. International Conference on Nanomaterials Science and Mechanical Engineering, Aveiro, Portugal, 16-18 July, 2018 //Diphenylalanine peptide nanotubes with different chirality: structures, properties, and applications (invited talk) 9. V. Slabov, K. Romanyuk, D. Alikin, K. Keller, S. Kopyl, A.L. Kholkin. IEEE International Symposium on Applications of Ferroelectrics (ISAF), Lausanne, Switzerland, July 14 – 19, 2019 //Diphenylalanine thin films for piezoelectric applications (oral presentation) |
